Answer:
According to eMedicine.com:
"Glutathione synthetase (GS) deficiency, first described in 1970, is a rare inborn error of glutathione metabolism characterized by severe metabolic acidosis, hemolytic anemia, and neurological problems. Biochemical findings include massive excretion of 5-oxoproline in the urine. In mild glutathione synthetase deficiency, which is characterized by hemolytic anemia, enzyme deficiency primarily occurs in erythrocytes.
Treatment of individuals who have been diagnosed with glutathione synthetase (GS) deficiency involves providing supplements to correct the metabolic acidosis and supplying antioxidants such as vitamin E and vitamin C. A combination of sodium citrate and citric acid (Bicitra) may be used as an oral medication and can maintain plasma bicarbonate levels within the reference range. Alternatively, bicarbonate may be used; however, very large doses may be needed."
You may view this information at its source here.
Glutathione synthetase deficiency is a very rare metabolic disorder that prevents your body from manufacturing its own glutathione. The GSS gene provides instructions for making an enzyme called glutathione synthetase. Mutations in the GSS gene cause glutathione synthetase deficiency.
This is not to be confused with glutathione deficiency, which is quite common.
According to the Physician's Desk Reference Listing for Immunocal, glutathione deficiency states include, but are not limited to : HIV/AIDS, infectious hepatitis, certain types of cancers, cataracts, Alzheimer's Disease, Parkinson's, chronic obstructive pulmonary disease, asthma, radiation, poisoning by acetaminophen and related agents, malnutritive states, arduous physical stress, aging, and has been associated with sub-optimal immune response.
Glutathione augmentation with Immunocal is a strategy developed to address states of glutathione deficiency.
Immunocal is the most effective, safe, and natural way to raise and sustain your glutathione.
You can order Immunocal here.